Stimulation of Hepatic Purine Biosynthesis by Orotic Acid
نویسندگان
چکیده
منابع مشابه
Studies of the biosynthesis of orotic acid.
* The data in this paper have been taken from a thesis presented by Ray Wu to the Graduate School of Arts and Sciences of the University of Pennsylvania in partial fulfilment of the requirements for the degree of Doctor of Philosophy. An abstract of a preliminary report of this work has appeared (1). Aided by a grant from the American Cancer Society, administered by the Committee on Growth of t...
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The experiments performed in this report were designed to investigate the mechanisms involved in the metabolic alterations associated with orotic acid-induced hepatic steatosis and the effect of fenofibrate, a stimulant of peroxisome proliferators-activated receptor alpha (PPARalpha), on these alterations. Male Wistar rats were divided into three experimental groups: 1) fed a balanced diet (C);...
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An animal model was used to determine the basis for the increase in purine biosynthesis that results from hepatic depletion of purine nucleotides, such as seen in patients with type I glycogen storage disease or following fructose administration. Mice were injected intravenously with glucose or fructose, 2.5 mg/g of body weight, and the animals were killed at 0, 3, and 30 min following carbohyd...
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Lipoproteins of rat plasma have been characterized by lipid analysis, preparative ultracentrifugation, electrophoresis on paper, and immunoelectrophoresis with specific antisera to Lu-lipoprotein, P-lipoprotein, and whole rat plasma. Similar techniques were used to characterize the lipoproteins released by livers perfused in situ with a suspension of erythrocytes in a medium initially free of r...
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Lipoproteins of rat plasma have been characterized by lipid analysis, preparative ultracentrifugation, electrophoresis on paper, and immunoelectrophoresis with specific antisera to Lu-lipoprotein, P-lipoprotein, and whole rat plasma. Similar techniques were used to characterize the lipoproteins released by livers perfused in situ with a suspension of erythrocytes in a medium initially free of r...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97075-4